Skin Health

Zinc plays an important role in the three skin functions such as morphogenesis, repair, and maintenance that provide protection and defense via the proteins and enzymes that are involved in these processes.Approximately 6% of the total concentration of the body’s zinc is located in the skin, which is present at levels five-fold higher in the epidermis when compared to the dermis .Zinc is known to stabilize cell membranes, act as an essential cofactor for several metalloenzymes (MMPs), be involved with superoxide dismutase, metallothionein, DNA, and RNA ploymerases, and participate in basal cell mitosis and differentiation . ¹

In induced (experimental) or clinical deficiency of zinc, skin lesions were common along with delayed wound healing and rough skin . During the early phases of wound healing, the induction of metallothionein may provide a source of zinc required for metalloenzymes to function. Superoxide dismutase and glutathione peroxidase are upregulated following cutaneous injury that, presumably, are zinc-dependent.¹

Hair Health

Zinc is essential micronutrient that play an important role in the metalloenzyme process of the body. Zinc is involved in protein and nucleic acid synthesis, and plays a role in various metabolic pathways and cellular functions. With regard to hair loss, zinc is a potent inhibitor of hair follicle regression, and accelerates hair follicle recovery. More specifically, transient zinc deficiency is a major pathogenesis in acrodermatitis enteropathica, resulting in hair loss. Arguments that zinc deficiency can be a disturbing factor for the growth of hair have been emerging since the 1990s^.2

Zinc Picolinate

The comparative absorption of zinc after oral administration of three different complexed forms was studied in 15 healthy human volunteers in a double-blind four-period crossover trial. The individuals were randomly divided into four groups. Each group rotated for four week periods through a random sequence of oral supplementation including: zinc picolinate, zinc citrate, and zinc gluconate (equivalent to 50 mg elemental zinc per day) and placebo. Zinc was measured in hair and erythrocyte before and after each period. At the end of four weeks hair, and erythrocyte zinc levels rose significantly (p less than 0.005 and p less than 0.001) during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. The results of this study suggest that zinc absorption in humans can be improved by complexing zinc with picolinic acid.³

                      ^{Changes in zinc level of erythrocytes                                                                                             Changes in zinc level of hair}

              ^{Asterisk indicates significant change (p < 0.001)                                                 Asterisk indicates significant change (p < 0.005)}

What is Pico zinc ®?

Pico zinc ® tablet contains 15 mg of elemental zinc in the form of zinc picolinate that can be used to prevent or treat zinc deficiency, and with immunomodulatory activity. As an essential trace element, zinc is of key importance in many biological processes. It plays an important role in the proper functioning of the both the innate and adaptive immune system. Zinc inhibits the production of pro-inflammatory mediators and prevents inflammation. It acts as an antioxidant, prevents oxidative damage and protects cells against DNA damage. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing.⁴

Recommended Daily Intake:
Adults and children over 12 years take 1 tablet daily after meal. Do not exceed recommended daily intake before consulting with your doctor or pharmacist.

Cautions: If you are suffering from renal diseases, food allergies or you are allergic to any of the ingredients of this product, consult with your doctor or pharmacist.

If you are taking this supplement with other supplements or drugs such as antacids and some antibiotics, be sure to observe the interval of two to four hours.

Ask a doctor or pharmacist before use if you are pregnant or breastfeeding.

Storage: Store below 30°C and keep away from light and
moisture. Keep out of reach of children.

Ref

1. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome
2. Analysis of Serum Zinc and Copper Concentrations in Hair Loss
3. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in human
4. https://pubchem.ncbi.nlm.nih.gov